陳春霞
福建省三明真菌研究所 三明365000

【中文摘要】 羧甲基茯苓多糖 (CMP) 2 5mg/kg～ 5 0 0mg/kg腹腔注射對(duì)ICR/JCL小鼠腫瘤U- 14 的抑制率為 75 .5 %～ 92 .7% ;CMP 5mg/kg～ 5 0mg/kg靜脈注射對(duì)昆明種小鼠S- 180 肉瘤的抑制率為34 .8%～ 61.0 % ;CMP 2 5mg/kg～ 10 0mg/kg靜脈注射對(duì)昆明種小鼠肝癌H2 2 的抑制率為 2 0 .1%～36.7% ;0 .2 5 %～ 0 .5 %的CMP對(duì)小鼠艾氏腹水癌瘤細(xì)胞的抑制率為 5 4 .7%～ 61.7%。CMP能明顯增強(qiáng)荷瘤小鼠腹腔巨噬細(xì)胞的吞噬功能 ,明顯增加小鼠脾抗體分泌細(xì)胞數(shù) (PFC)以及特異的抗原結(jié)合細(xì)胞數(shù) (SRFC) ,明顯增強(qiáng)小鼠對(duì)牛血清白蛋白 (BSA)誘導(dǎo)的遲發(fā)型超敏反應(yīng) (DTH) ,明顯增強(qiáng)小鼠脾T細(xì)胞生長(zhǎng)因子 (TCGF)的生長(zhǎng) ,這可能是其增強(qiáng)免疫應(yīng)答功能及抑瘤率的機(jī)制之一

【英文摘要】 The experiment result showed that the suppressive rate of 25mg/kg～500mg/kg CMP by abdominal cavity injection on ICR/JCL mice tumor U -14 was 75.5%～92.7%, the suppressive rate of 5 mg/kg～50mg/kg CMP by vein injection on Kumming mice S -180 was 34.8%～61.0%, the suppressive rate of 25mg/kg～100mg/kg CMP by vein injection on Kumming mice liver cancer H 22 was 20.1%～36.7%,and the suppressive rate of 0.25%～0.5% CMP on the cell of Ellce ascitic tumor of the mice in vitro was 54.7%～61.7%. CMP could significantly improve the phagocytosis of abdominal cavity macrophage of the mice with tumor, greatly increase the number of the spleen PFC and SRFC, significanfly strengthen the DTH induced by BSA and stimulate the growth of TCGF, which was suggested to be one of the mechanisms of enhancing the immunological responsive function and tumor-suppressive rate of the mice.

【中文關(guān)鍵詞】 羧甲基茯苓多糖; 抗腫瘤活性; 免疫調(diào)節(jié)功能; T細(xì)胞生長(zhǎng)因子
【英文關(guān)鍵詞】 Carboxymethylpachymaran; Antitumor activity; Immunoregulatory function; T cell growth factor

【文獻(xiàn)出處】 食用菌學(xué)報(bào),Acta Edulis Fungi,編輯部郵箱,2001年03期 【DOI】CNKI:SUN:SYJB.0.2001-03-007